April 7, 2021

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Why Is Gene Synthesis a Revolutionary Tool for Biology Research?

3 min read

The most significant reason why gene synthesis is completely changing biology research as we know it is that it doesn’t require a DNA template.

Traditional DNA replication requires a template of a DNA strand to assemble natural or recombinant DNA molecules. In gene synthesis, you can build virtually any DNA sequence by customizing the entire process.

You can use a single-stranded molecule and add nucleotides to it to create a template for designing a complementary strand.

Thanks to custom gene synthesis technologies, we can now transform biology research and life itself.

Accelerating Biology Research in Various Fields

Before gene synthesis existed, scientists relied on replicating one gene at a time. With a custom gene synthesis, they can synthesize, sequence, and amplify much longer genes at a time, including entire genomes.

This saves a significant amount of time and money. It also enables scientists to create DNA sequences that are not available in nature.

What does all of this mean for biology research?

Scientists now have a powerful tool for quickly and accurately developing new enzymes that may help combat cancer. When a new virus appears, one can synthesize its genome to develop a safe and effective vaccine quickly.

They can design or reprogram the vascular tissues of plants to eliminate the risk of plant diseases and protect them from various pests. That can be critical in agriculture, as crops can produce better yield and be much healthier for consumption.

They can also help protect the air, water, and soil by synthesizing environmental pollutants to break them down completely.

They can also help develop sustainable biofuels, with the aid of metabolic engineering. Instead of using chemical synthesis or using plant extracts to produce natural products, they can leverage biosynthetic pathways.

Improving Codon Optimization

Codon optimization plays a big role in protein expression, especially in a heterologous system, that is, a model organism or host cell.

Codon usage has different frequencies in different species, which is why there are very low levels of protein expression in heterologous genes. Therefore, heterologous protein expression often leads to improper protein folding.

However, gene synthesis can prevent this change in the final amino acid sequence through codon optimization.

It can modify a genetic code to alter the DNA sequence and ensure efficient and effective heterologous protein expression. It can fully optimize DNA-based transcription and translation, process and stabilize mRNA, and ensure proper protein folding.

Discovering or Designing Genetic Mutations

Gene synthesis can help researchers develop or design mutations of various novel types of proteins, which can be of massive help in numerous research fields.

They no longer need to use chemical mutagens or UV radiation to damage the DNA of various live cells or organisms. Needless to say, such processes often lead to useless phenotypes of mutated genes and even the death of cells.

With custom gene synthesis, researchers can develop random or systematic genetic mutations both quickly and accurately, without any DNA damage.

It eliminates the need for site-directed mutagenesis, which is very time-consuming and error-prone.

This is just the tip of the colossal iceberg of gene synthesis, as this revolutionary tool brings many more benefits to the table. It has numerous applications in a wide range of fields, and we are certainly yet to unlock its full potential.

If you need to quickly and accurately analyze or replicate long DNA sequences, consider finding a reliable custom gene synthesis service. In just a matter of weeks, you will be able to work with custom-synthesized, full-length DNA sequences.

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